Pre-transplant diabetes mellitus is a risk factor for non-relapse mortality, especially infection-related mortality, after allogeneic hematopoietic SCT

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Reducing transplant-related mortality after allogeneic hematopoietic stem cell transplantation.

BACKGROUND AND OBJECTIVES Transplant-related mortality (TRM) following allogeneic hematopoietic stem cell transplantation (HSCT) has been reported to be related to disease stage, duratiion of disease and type of donor. Furthermore, the outcome of transplants performed in the 1990s appears to be better than that of transplants done in the previous decade. The aims of this study were to determine...

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Allogeneic hematopoietic stem cell transplantation in the elderly. Predicting the risk for non relapse mortality.

We have retrospectively reviewed 137 medical records of patients older than 50 years receiving an allogeneic hematopoietic stem cell transplantation (HSCT) between January 1997 and July 2013. Median follow up was 1.3 years. Sex, age, diagnosis, disease stage, comorbidities (according to HCT-CI score), type of donor, histocompatibility, conditioning regimen and graft-versus-host disease (GVHD) p...

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Extramedullary relapse after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia is a contributor to post-transplant mortality but risk factors for, and outcomes

©F rr ta St ort i F o nd ati o phylaxis. Extramedullary relapse was biopsy-confirmed in all but one patient, who had obvious progression of proven chloromas that were still present at the time of HSCT. Twenty-four of 26 patients (92%) who had extramedullary disease noted at the time of post-HSCT relapse had bone marrow biopsies confirming the presence (n=2) or absence (n=22) of bone marrow recu...

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Venous thromboembolism is associated with graft-versus-host disease and increased non-relapse mortality after allogeneic hematopoietic stem cell transplantation

Although venous thromboembolism rates and risk factors are well described in patients with cancer, there are limited data on the incidence, risk factors and outcomes of thrombosis after allogeneic stem cell transplantation, a curative therapy for patients with hematologic malignancies. We aimed to determine the incidence and risks associated with venous thrombosis in allogeneic stem cell transp...

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Increased risk of infection and mortality in women after cardiac surgery related to allogeneic blood transfusion.

BACKGROUND Infection and mortality rates are greater in women than in men after cardiac surgery. This study was conducted to assess whether allogeneic blood transfusion could partially account for this gender difference, as transfusion has been associated with immunomodulation. METHODS A cohort study was conducted in 380 patients at the University of Rochester Medical Center. Subjects were ad...

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ژورنال

عنوان ژورنال: Bone Marrow Transplantation

سال: 2015

ISSN: 0268-3369,1476-5365

DOI: 10.1038/bmt.2014.315